1. There’s something in the RSS Feed about Parkinson’s disease in the middle column of my home page, about halfway down, about “MCI” or “minor cognitive impairment” — which seems to be a precursor to Parkinson’s Disease Dementia. Earlier today, leaving the bedroom and heading for the shower, I saw a big, black bug for a fleeting second on the door jamb in the bedroom. It quickly vanished as I looked at it directly. Yesterday, something furry poked out between the couch and chair… both dogs were asleep at Gail’s feet, so it weren’t them. Today, I gets an e-mail from a colleague asking me to call an 800-number to record something on a draft she sent, but she asked me to review the draft first. I did and made comments and responded to her e-mail. She wrote back that she hadn’t received the file yet. I thought she was talking about the file I would create by calling the 800 number. I FORGOT ABOUT THE DOCUMENT I HAD EDITED. I apologized and sent it to her just now.
Gail and I just got back from our midday runabout. It’s been so freakin’ hot lately that neither one of us really wanted to go out or do anything, but it’s only 86 now, so what the hell. Went to the mailbox first. Then, I wanted a bottle of brandy. (On the Simpsons last night, Mr. Burns was clutching a glass of brandy. It made me want a glass of brandy. I am an easily-influenced person.)
Night before last, I recall dreaming. And I recall THINKING in my dream, “Wow! This is gonna make a GREAT blog entry!” Then when I woke up… I FORGOT WHAT THE DREAM WAS!!!
Ladies and gentlemen, may I introduce you to the first episode of “Undercover Trucker: How I Saved America by Truckin’ Towels for the Taliban.”
I remember around 2002-2003, when I was weaning myself off of levodopa (I figured and my neurologist at the time agreed that my symptoms weren’t all that bad unmedicated, so we felt we could put off the side effects of L-Dopa therapy by putting it off for a few years). All the talk in Parky Land was about the nutritional supplement CoQ10. All sorts of anecdotal stories on the Parky chat boards about how someone knew someone who took CoQ10 for a month and was all better now… that sort of thing.
I asked my neurologist at the time what he thought of all this. He said there was no credible scientific evidence to support any of the claims. However…
“It’s like my mama used to say about eating chicken soup when you have a cold. It couldn’t hurt!”
Well, CoQ10 is expensive. I had been taking it for a little while and hadn’t seen any noticeable benefit, so after talking to the neurologist I just stopped taking it.
Now, it turns out my neurologist was right. It’s not a bad thing for you. It just doesn’t do much for Parkinson’s disease.
The mitochondria is the part of the cells that produces energy. The first step in producing energy in the mitochondria is Complex I (NADH : ubiquinone oxidoreductase). In people with Parkinson’s Disease, Complex I is reduced in activity in the substantia nigra, which is the part of the brain primarily affected in Parkinson’s Disease. Complex I needs Coenzyme Q10 in order to function properly. However, energy production has no direct effect on increasing dopamine formation It has been claimed that Coenzyme Q10 is a potent antioxidant that can partially recover the function of dopaminergic neurons (the cells involved in Parkinson’s Disease).
Coenzyme Q10 was found to be completely ineffective in Parkinson’s Disease in daily doses of 200mg, 300mg, 400mg, 600mg, and 800mg. Only one Coenzyme Q10 study has ever shown any improvement in Parkinson’s Disease, using 360mg, but the effects were mild and were only assessed for four weeks. Daily doses of 300mg, 600mg and 1200 mg of Coenzyme Q10 failed to improve the symptoms of Parkinson’s Disease, but reduced the rate of deterioration. Coenzyme Q10 was safe to use in doses of 1200mg, 1800mg, 2400, and 3000. Plasma levels of Coenzyme Q10 did not increase in doses above 2400mg.
So, keep shelling out big bux for the CoQ10… or get a can of chicken noodle soup. You’ll get the same result.
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